As shown in Table 4, haplotype analysis with respect to different SNPs in CALM1 gene using Haploview 4.0 got one positive haplotype: SNP8C-SNP01A-SNPl3C-SNPl4C-SNP02C-SNP3T-SNP4G-SNP05T-SNP011C, its haplotype frequencies were higher than 10%, and that haplotype distributions were significantly different between case group and control group, which again indicated that CALM1 gene was possible to be a susceptibility gene of AIS. This evidence concerns the gene CALM1 and androgen insensitivity syndrome.