Single nucleotide polymorphisms (SNPs) in the genes for estrogen receptor a (ESR1) [8], estrogen receptor b (ESR2) [9], matrilin 1 (MATN1) [10], melatonin receptor 1B (MTNR1B) [11], tryptophan hydroxylase 1 (TPH1) [12], interleukin-6 (IL-6), and matrix metalloproteinase-3 (MMP-3) [13] have been reported to be associated with AIS predisposition. The gene discussed is MATN1; the disease is androgen insensitivity syndrome.