Thus we speculated that these three SNPs may not correlate with the pathology of AIS but possess strong linkage disequilibrium with certain pathogenic gene, and on the other hand, we deduced that base change of these three SNPs might affect the expression of CALM1 gene which leads to the increased expression of CaM, resulting in the occurrence of scoliosis. The gene discussed is CALM1; the disease is scoliosis.