NAMPT and colorectal cancer: Nevertheless, the result of the present study showed that HCT-116 cells secrete and express visfatin protein endogenously which may apply its possible carcinogenous effects by the autocrine manner, although lymphocytes and neutrophils and other immune system cells existing in stroma compartment of cancerous tissue secrete this adipokine as an inflammatory phase protein, due to the inflammation status of colorectal cancer.