There is an augmentation in the expre-ssion of vascular adhesion molecules including CD54 (ICAM1) and CD106 (VCAM1) in oral lichen planus in subepithelial vascular network which is induced by a number of cytokines such as TNFα, IL1 and IFN-γ produced by macrophages, Langerhans cells, lymphocytes and keratinocytes (22). This evidence concerns the gene TNF and oral lichen planus.