VEGFA and lichen planus: Elevated VEGF has also been observed in the saliva of patients with oral lichen planus in Mittal et al.'s survey; VEGF secreted by macrophages and other cells of the immune system increases vascular proliferation and endothelial cell migration and is an important factor in the initiation and progression of angiogenesis which is severely raised in patients with oral lichen planus; they also stated that angiogenesis plays a significant role in the etio-pathogenesis and progression of lichen planus (20).