The presence of PKM2 and MAPK8IP2 gene expression were determined by PCR in ameloblastoma and ameloblastic carcinoma com-paring with normal follicle (controls).c.37G>A polymorphism in PKM2 and the c.196C>T polymorphism in MAPK8IP2 were not recognized in all of the sample cases. Here, MAPK8IP2 is linked to ameloblastic carcinoma.