We have measured ascorbate levels, HIF-1α protein levels, and three HIF-1-controlled pro-survival target gene products; Bcl-2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3), glucose transporter 1 (GLUT-1), and vascular endothelial cell growth factor (VEGF), in tumor and patient-matched adjacent normal tissue and compared these results to clinico-pathological data. The gene discussed is HIF1A; the disease is neoplasm.