FLNB and skeletal dysplasia: Autosomal dominant mutations of FLNB (missense mutations, small in-frame deletions or insertions) cause a group of skeletal dysplasias, including Larsen syndrome (LS; OMIM 150250), atelosteogenesis I and III (AOI and AOIII; OMIM 108720 and 108721), and boomerang dysplasia (BD; OMIM 112310) [1], [2], [3].