As summarized the Table 3, the positive expression of p-Mnk1 and p-eIF4E protein, clinical stages, cervical lymph node metastasis (LNM), treatment strategy for NPC patients (radiation therapy alone or chemotherapy alone, and combination of radiotherapy and chemotherapy) were significantly correlated with overall survival of NPC patients (p = 0.05, p = 0.001, p<0.001, p = 0.001 and p = 0.004, respectively). Here, MKNK1 is linked to nasopharyngeal carcinoma.