In the current study, we have investigated the expression pattern of p-eIF4E and p-Mnk1 protein in 272 NPC cases and 85 non-cancerous nasopharyngeal epithelial specimens by Immunohistochemistry (IHC) and determined the correlation between the expression of p-eIF4E and p-Mnk1 and clinicopathologic/prognostic characteristics in NPC. Here, EIF4E is linked to nasopharyngeal carcinoma.