Also, there was no significant difference in the positive percentage of p-Mnk1 and p-eIF4E expression between the matched primary and relapsed NPC despite the higher expression of both proteins in the matched relapsed NPC (94.7% vs 84.2% for p-Mnk1 and 89.5% vs 73.7% for p-eIF4E). The gene discussed is MKNK1; the disease is nasopharyngeal carcinoma.