The significantly abnormal over-expression of p-eIF4E protein is found in a number of tumors including non-small cell lung cancer, breast cancer, gastric cancer, colon cancer, prostate cancer, penile squamous cell carcinoma, head and neck cancer and primary central nervous system lymphoma [24]–[25], [27]–[32]. The gene discussed is EIF4E; the disease is primary central nervous system lymphoma.