SCA platelets are reported to present an increased expression of adhesion molecules and markers of platelet activation, such as CD40 ligand (CD40L), on their surface [14], [17], [18] and produce higher levels of potent inflammatory cytokines, such as TNFSF14 (Tumor necrosis factor ligand superfamily member 14; LIGHT; CD258) [19]. The gene discussed is CD40LG; the disease is autosomal dominant cerebellar ataxia.