This BDNF’s neuroprotective action was blocked by pretreatment with an ERK1/2 inhibitor, U0126, but not with an PI3-K inhibitor, wortmannin [36], suggesting a central role of the ERK1/2 pathway in mediating the neuroprotecive effect of BDNF on H-I brain injury in developing brain. Here, BDNF is linked to brain injury.