The percentage of CTTN overexpression in informative ESCC tumor tissues was up to 63.6% (126/198), which was significantly higher than that in normal esophageal epithelia (26.8%, 53/198, P<0.001, Wilcoxon signed rank test, Figure 1B and Table 1). The gene discussed is CTTN; the disease is esophageal squamous cell carcinoma.