Top, highly significant canonical pathways included IFN signaling, antigen presentation, interferon regulatory factor (IRF) activation by cytosolic pattern recognition receptors, retinoic acid-mediated apoptosis signaling, protein ubiquination pathway, pathogenesis of multiple sclerosis, and role of retinoic acid-inducible gene (RIG)-like receptors in anti-viral immunity. Here, TRIM63 is linked to multiple sclerosis.