NEC-DUE2 was isolated from a lymph node metastasis of a pT4a N2b M1a (LYM) L1 V1 Pn1 G3 (Ki-67 index: 80%) large-cell NEC located at the right colic flexure of a 71-year old, male Caucasian without a history of neoadjuvant chemotherapy. The gene discussed is MKI67; the disease is neuroendocrine carcinoma.