NEC-DUE1 originated from one of two atypically resected liver metastasis (Ki-67 index: 80%) of a 71-year old, male Caucasian with a history of neoadjuvant chemotherapy with cisplatin/etoposide and extended gastrectomy for a pT3 N1 L1 V1 G3 large-cell NEC at the gastroesophageal junction. This evidence concerns the gene MKI67 and neuroendocrine carcinoma.