CD274 and breast carcinoma: This is especially the case with some of the INTEGRIN (CAV1, PXN, ZYX, VCL), RHO (TLN1, CFL1), and calpain1/2 genes.[14]–[21] Basal B breast cancer cell lines have been shown to be more invasive in Boyden chamber experiments, providing more evidence that high PD-L1 cell lines behave in a more invasive manner.