UCN2 and connective tissue disorder: The distinct nucleo-cytoplasmic pattern observed with the serum of the index case described above, is different from the cytoplasmic and nuclear patterns that are usually observed in some connective tissue diseases (anti-synthetase syndrome with anti-Jo1, necrotizing myositis with anti-SRP, systemic lupus erythematosus (SLE) with anti-RiboP autoantibodies or primary biliary cirrhosis with anti-mitochondria antibodies) shown in FIGURE 1.