ACE and Duchenne muscular dystrophy: Recently, in the search for novel drug-treatment strategies for DMD, we showed efficacy of the combination of lisinopril (L), an angiotensin converting enzyme (ACE) inhibitor, and spironolactone (S), an aldosterone antagonist in mice lacking dystrophin, and heterozygous for utrophin (utrn+/−;mdx, het mice) [15].