We previously reported increased expression of IGFBP-5 in primary dermal fibroblasts of patients with SSc [2], and increased levels of IGFBP-5 mRNA and protein in lung tissues of patients with IPF and SSc [3] and in primary fibroblasts cultured from these tissues [3], [4]. Here, IGFBP5 is linked to idiopathic pulmonary fibrosis.