The AA changes were more numerous in the viruses from Guangzhou, including the first reported dengue case in Foshan, than in the viruses from dengue epidemics outside of Guangzhou (NS1 of DENV-3: t = 2.3, p = 0.034; NS1, NS2B and NS3 of DENV-2: t = 2.7, 2.9, Z = 2.2; p = 0.024, 0.016, 0.042, Table 4). The gene discussed is KRAS; the disease is dengue disease.