Specifically, the top deregulated genes for OA vs. NT samples include the DPM2, MUS81, VAMP2, ZBTB33, NUP62, RHBDD1, PDZD7, PLEKHG4, ABCG1, TCEA3, etc. Several of these genes have been identified to be involved in the development RA or OA samples, including COL2[24], Gal-9[25], [26], MUS81[27] and ABCG1[28]. The gene discussed is VAMP2; the disease is rheumatoid arthritis.