The top 10 up-regulated and down-regulated genes for RA vs. NT were listed in Table 2, which include the DCTN1, GABRR3, SOX18, ALPK2, UCP2, GGTL3, GNGT2, ABHD11, ETV3, NPCDR1, etc. The gene with the most significant expression difference between RA and OA is Dynactin subunit 1 (DCTN1), which presents a ∼1437.67 fold higher expression in RA samples. Here, ALPK2 is linked to rheumatoid arthritis.