Notably, the relevant genes, which include the ATP6, SCO2, CYTB, DN1, COX1, ANT1, are mainly function in oxidative phosphorylation, whereas dysfunction in oxidative phosphorylation related genes is closely related to the systemic juvenile idiopathic arthritis and endemic osteoarthritis [40], [41]. Here, IGHD6-13 is linked to systemic-onset juvenile idiopathic arthritis.