Specifically, the top deregulated genes for OA vs. NT samples include the DPM2, MUS81, VAMP2, ZBTB33, NUP62, RHBDD1, PDZD7, PLEKHG4, ABCG1, TCEA3, etc. Several of these genes have been identified to be involved in the development RA or OA samples, including COL2[24], Gal-9[25], [26], MUS81[27] and ABCG1[28]. Here, NUP62 is linked to rheumatoid arthritis.