In conclusion, this study demonstrated that CNE increased insulin sensitivity appears to be related to not only increased phosphorylation of AMPK but also increased protein contents of GLUT4 in C3-treated group in skeletal muscle and in C2-treated group in adipose tissue, whereas it is related to a reduction in G6Pase expression, which is one of rate-limiting enzymes of hepatic gluconeogenesis, resulting in reduced glucose level in HF-fed mice. The gene discussed is SLC2A4; the disease is hydrops fetalis.