Similarly in one of the experiment downregulation of hnRNPA1 in nuclear compartment of U87 glioma cells after treating with small molecule against GSK3beta and Akt kinase, Moreover, downregulation of hnRNPA1 and SF2/ASF1 in U373 glioma cell were also observed after Akt RNAi and GSK3beta RNAi (Figure 2), this further opening the avenue of multifunctional role of GSK3beta including regulation of splicing factor expression by which could restrict the origination of alternative genetic splice variant or alternative apoptotic escape pathway. This evidence concerns the gene SRSF1 and central nervous system cancer.