BIRC5 and central nervous system cancer: Similarly, Anxa7 protein restoration using small molecule against GSK3beta was found to be an additional advantage along with downregulation of MCL1 and Survivin in glioma cells, which is supported by the earlier group; the relevance of radiation induced glioma's sensitization after downregulation of MCL1 and Survivin using Akt kinase inhibitor in EGFR context [25, 26].