A low GL was found to improve the efficiency of weight loss advice over 4 weeks [21] and improve risk factors for coronary heart disease including high-density lipoprotein cholesterol (HDL-C), triglycerides, and C-reactive protein (CRP) over 4 weeks to 6 months [21–23] compared with a low-fat diet, in young overweight and obese adults without diabetes. The gene discussed is CRP; the disease is diabetes mellitus.