These effects of foalte may affect the susceptibility of gastric cancer.4,5 Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism, is responsible for the circulation form of folate and 5-methyltetrahydrofolate which is involved in DNA synthesis and methylation.6 The activity of MTHFR is controlled mainly by the genetic polymorphisms and shows variation between different individuals.7,8 MTHFR C677T (rs1801133) and MTHFR A1298C (rs1801131) polymorphisms are associated with a reduced activity of MTHFR. Here, MTHFR is linked to gastric cancer.