Low intracellular magnesium levels negatively affect the transportation of cellular glucose, tyrosine kinase activity, post-receptor insulin action and secretion of insulin from the pancreas.22,23 In a study by Rodriguez-Moran and Guerrero-Romero, post-receptor insulin resistance was related to the TNF-alpha concentration, which is associated with low serum magnesium levels.24 This evidence concerns the gene INS and Insulin resistance.