PTGS2 and cancer: We note that genes (nodes) ranked high exclusively by the eigenvector centrality measure (i.e., STAT1, JAK2, JAK1, PIAS3, COX2, GRIM19) are all neighbors (directly downstream or upstream in the pathway) of STAT3, which plays a leading role in cancer inflammation and immunity, and is a validated target for cancer therapy (Yu et al., 2009).