For instance, when the integrated breast cancer pathway is restricted by the five NCI60 breast tumor cell lines based on their respective gene expressions, BRCA1 ranked highest by degree and spectral gap centralities for cell lines MCF7, MDA_MB_231 and BT_549, while MAX ranked highest by the same measures for cell lines HS578T and T47D. The gene discussed is BRCA1; the disease is breast cancer.