NFATC1 and Hodgkins lymphoma: While in peripheral blood lymphocytes, in Jurkat T cells, and in other lymphoid cell lines in which NFATc1 is expressed the DNA of promoter islands is de-methylated, inactivation of human NFATC1 gene in several Hodgkin’s lymphoma cells lines is correlated with the methylation of all CpG dinucleotides within the P1 promoter (12).