Neuronal injury is closely tied to astrogliosis, and we and others have previously shown that bioluminescence intensity in the GFAP-luc mice correlates significantly with astrogliosis assessed by immunohistochemistry and with neural injury in brain injury models of excitotoxicity and experimental autoimmune encephalomyelitis (22, 23). Here, GFAP is linked to experimental autoimmune encephalomyelitis.