RPS19 and anemia: It has been demonstrated that haploinsufficiency of ribosomal proteins Rps14 and Rps19 causes symptoms resembling DBA in zebrafish such as anemia and craniofacial dysplasia, and also that treatment with L-Leucine reduces the severity of both anemia and developmental deficits (Payne et al., 2012; Boultwood et al., 2013).