The activation of kit regulates important cellular functions, including proliferation, migration, apoptosis, chemotaxis and adhesion that are critical for the development and maintenance of several cell types—hematopoietic cells, mast cells, melanocytes, gametocytes, and interstitial cells of Cajal (ICC) (Kitamura and Go, 1979; Huizinga et al., 1995; Bernex et al., 1996; Wu et al., 2000). Here, KIT is linked to intrahepatic cholangiocarcinoma.