While there were no major differences in secretion of CXCL2/MIP-2 and CXCL1 in unstimulated macrophages from either SEMA7A scramble control or SEMA7A silenced mammary tumor-bearing mice, there were significant (p < 0.01) differences in the production of both these chemokines from LPS-stimulated (100 ng/ml) cultures (Figures 6A,B). The gene discussed is CXCL1; the disease is breast cancer.