Thus, the excess of free plasma and hippocampal CORT in VAD rats, which is associated with a decreased binding capacity of plasma CBG and a hyperactivity of hippocampal 11β-HSD1, could contribute to the appearance of spatial memory deficits, elevated anxiety-like behavior and hippocampal neurogenesis alterations observed after 14 weeks of VAD. Here, SERPINA6 is linked to Anxiety.