Mutations in the Syntaxin Binding Protein 1 (STXBP1) gene have been linked with two distinct but related forms of the disorder including early onset epileptic encephalopathy with suppression-bursts (EESB) associated with Ohtahara syndrome, and more recently with infantile spasms (IS) associated with West syndrome (Barcia et al., 2013). Here, STXBP1 is linked to genetic developmental and epileptic encephalopathy.