STXBP1 and infantile spasms: Mutations in the Syntaxin Binding Protein 1 (STXBP1) gene have been linked with two distinct but related forms of the disorder including early onset epileptic encephalopathy with suppression-bursts (EESB) associated with Ohtahara syndrome, and more recently with infantile spasms (IS) associated with West syndrome (Barcia et al., 2013).