CTCF and Cornelia de Lange syndrome: Fig. S2) and performed ChIP-sequencing for NIPBL, cohesin and CTCF using HB2 cells (1-7HB2) [25] enriched in G1 phase (Suppl. Fig. S3A) and for NIPBL in lymphoblastoid cells (LCL; B-cell population immortalised by EBV-transformation) derived from a normal control (N5) and CdLS patients (PT1, PT9).