BICC1 and neoplasm: Interestingly, BICC1 is a negative regulator of Wnt signaling [80] and when comparing expression of tumor and normal tissue we observed differentially expressed Wnt signaling genes, APC (fold change -4.75027), GSK3B (fold change -3.35309), and CTNNB1 (fold change -1.73148), yet when the expression was compared to other cholangiocarincomas, no difference was observed.