We have demonstrated that KSHV interaction with HMVEC-d cell surface EphA2 results in the recruitment of the macropinosome associated c-Cbl-integrin-myosin IIA-complex in the LR regions as well as the amplification of Src, PI3K, and c-Cbl activation which resulted in the promotion of macropinocytic entry and infection [23]. This evidence concerns the gene CBL and infection.