With regard to risk stratification, the most robust identification strategy to date is detecting germline mutations in genes that cause these and other hereditary colon cancer syndromes (e.g., APC mutations in FAP and MSI and mutations in MMR genes in Lynch syndrome, MUTYH biallelic mutations in MAP, and BMPR1A in juvenile polyposis, etc.)[146]. This evidence concerns the gene MRC1 and Lynch syndrome.