All of the patients with prostate cancer had weak expression of PEDF, 2 patients with high-grade prostatic intraepithelial neoplasia showed strong PEDF expression, 3 patients had moderate expression, and 6 patients with high-grade prostatic intraepithelial neoplasia weakly expressed PEDF. Here, SERPINF1 is linked to prostate intraepithelial neoplasia.