LMAN2 and cancer: Aiming to discover specific patterns in the secretome (extracellular proteome), which presumably triggers immune response in cancer patients and is believed to be enriched in biomarkers due to the humoral immune response, they identified two novel biomarkers, Glod4, a glyoxalase-domain containing protein, and a C-terminal fragment of agrin, a heparansulfate proteoglycan resident in basement membranes, and several other differentially expressed proteins or protein fragments, such as PGAM1, syntenin, aldolase C, LMAN2, VIP36, and Rad23b.