Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) was also determined as overexpressed in gastric cancer by immune-staining and proposed as a possible prognostic biomarker [193], and similar findings were confirmed for kallikrein 12 (KLK12) [194], and plasma membrane protein solute carrier family 3 member 2 isoform b (SLC3A2) [195]. This evidence concerns the gene LGR5 and gastric cancer.