Immunohistochemistry was also used to determine differential expression of endothelial cell protein C receptor (EPCR), as well as increased metalloproteinase-2 (MMP-2) and reduced β-catenin levels, which may play important roles in initiation, progression, and metastasis of non-small-cell lung cancer [81, 82]. This evidence concerns the gene PROCR and non-small cell lung carcinoma.