GREM1 and renal cell adenocarcinoma: Heterogeneous methylation as determined in the CGI of GREM1 in RCC (11) may lead to varying statistical associations with clinicopathological parameters; thus, our previous findings of GATA5 CGI methylation as a potential prognosticator for RCC would be strengthened if another GATA5 methylation locus could be identified to demonstrate association with an unfavorable prognosis.