In contrast, univariate Cox regression analysis revealed GATA5 methylation as a strong parameter in the RCC [P<0.001; hazard ratio (HR) = 17.8; 95% (CI) confidence interval, 4.89–65.1] and ccRCC (P<0.001; HR = 13; 95% CI, 3.57–47.4; Table IVA) tissue groups. The gene discussed is GATA5; the disease is renal cell adenocarcinoma.