Comparison of CGI methylation of GATA3 and GATA5 in ccRCC and papillary renal cell carcinoma showed significant statistical differences for the mean GATA3 (P=0.006) and GATA5 (P=0.015) relative methylation indices observed in both histological entities (Table III). This evidence concerns the gene GATA3 and nonpapillary renal cell carcinoma.