GATA3 and cancer: The GATA1, GATA2 and GATA3 members of the GATA transcription factor family are functionally involved in cellular lineage determination (13) while the GATA4, GATA5 and GATA6 are mainly involved in epithelial differentiation and are suggested to play a critical role in tumorigenesis of cancer with endo- or mesodermal origins (13).