Mean methylation for both CGIs (GATA3 and GATA5) was significantly higher in advanced vs. localized (P=0.024 and P<0.001, respectively) and in metastasis-negative (M0) vs. metastasis-positive (M+) tumors (P=0.003 and P<0.001, respectively; Fig. 3C and D) of the RCC tissue group. This evidence concerns the gene GATA5 and renal cell adenocarcinoma.