The OptiMAL-IT test strip contains the antibody 17E4, which specifically detects P. falciparum lactate dehydrogenase (pLDH) and a pan-malaria antibody (19G4) that identifies pLDH from P. vivax, P. malariae and P. ovale as well as P. falciparum. BinaxNOW® Malaria is the only test approved by the US FDA and contains an antibody that detects P. falciparum-specific histidine rich protein 2 (HRP-2) and a pan-malaria antibody that detects Plasmodium aldolase, a glycolytic enzyme produced by all species of the parasite. Here, HDGFL2 is linked to malaria.