ADAM10 and neoplasm: We then reanalyzed the number of ADAM10+ tumor cells based on different histological types and found that osteoblastic osteosarcoma had significantly more ADAM10+ tumor cells compared with chondroblastic and fibroblastic osteosarcomas (Additional file 1: Figure S1, lower graph), suggesting that ADAM10 might be involved specifically in the pathogenesis of osteoblastic osteosarcoma.