Assuming a dominance model, a significant association was found between the MetS score and the following SNPs: CYP2C19 rs4244285 (P = 4.9×10-4), GABRA2 rs279871 (P = 0.018), NPY rs16147 (P = 0.029) and TPMT rs1142345 (P = 0.003). The gene discussed is NPY; the disease is metabolic syndrome.