Despite the fact that associations of the three SNPs (rs279871, rs16147, rs1142345) in the GABRA2, NPY and TPMT genes, with the MetS score do not remain significant after multiple testing correction, we can observe an additive genetic effect of these variants in the MetS score (Figure 3A), since it increases with the growing number of genetic risk factors (ANOVA for trend P < 0.001). The gene discussed is NPY; the disease is metabolic syndrome.