The proliferating CD4+ responder immune cells cultured with RA CD11b+ CD11c- cells were also shown to have reduced expression of IL-17 IFN-gamma (Figure 4C) and IL-10 (Additional file 2: Figure S2) but no change in IL-4 production as determined by intracellular cytokine staining (Figure 4C). This evidence concerns the gene ITGAX and rheumatoid arthritis.