ADM and Sepsis: At the time of admission, ADM concentrations were associated with the severity of disease: ADM was correlated with the APACHE II score (r = 0.46; P <0.0001), and were significantly (P <0.001) higher in patients presenting with severe sepsis or septic shock (93 (50 to 232) pg/mL) compared to those with sepsis only (48 (32 to 72) pg/mL, P <0.0001) (Figure 1).