In contrast to the HIF-1α KO mice with laser-induced choroidal neovascularization (CNV), the HIF-1α KO mice with OIR showed no significant difference from the wild-type mice in retinal levels of HIF-1α and VEGF as well as in the number of preretinal neovascular cells [28]. This evidence concerns the gene HIF1A and choroidal neovascularization.