SMAD3 and coronary artery disorder: The area under the Receiver operating characteristic curves (AUCROC) indicated that both TGF-β1 (AUCROC: 0.678, 95% confidence interval [CI]: 0.633–0.723) and SMAD3 (AUCROC: 0.715, 95% CI: 0.672–0.758) were the more potent biomarkers for CAD, compared with Lpa (AUCROC: 0.574, 95% CI: 0.525–0.623), ApoA1 (AUCROC: 0.561, 95% CI: 0.512–0.609), uric acid (AUCROC: 0.663, 95% CI: 0.617–0.710), BUN (AUCROC: 0.581, 95% CI: 0.533–0.630), or TG (AUCROC: 0.545, 95% CI: 0.496–0.594) (Figure4).