STAT3 and neoplasm: To evaluate whether the trends of endothelial cell-induced phosphorylation of STAT3, Akt, and ERK in tumor cells in vitro translate into increased phosphorylation levels in vivo, we used the SCID mouse model of human tumor angiogenesis in which we engineer cervical cell adenocarcinomas vascularized with human functional blood vessels that anastomize with the mouse vasculature [27-29].