We hypothesize that the primary pathway by which GTCs in Polyphenon E, specifically EGCG, will induce prostate epithelial cell apoptosis, is via the proteasome inhibition pathway (accumulating IκBα and p27 proteins, decreasing NFκB activation), resulting in inhibition of prostate cell survival and induction of apoptosis, thereby decreasing progression from HGPIN or ASAP to prostate cancer. This evidence concerns the gene NFKB1 and Familial prostate cancer.