We have proposed a novel cumulative model in which six major mechanisms of GTP chemoprevention (Figure 1): proteasome inhibition, cell cycle arrest, inhibition of cell proliferation, apoptosis, suppression of progression and inhibition of metastasis, work sequentially and in concert through the NFκB pathway to exert chemopreventive action on prostate cancer cells [36]. Here, NFKB1 is linked to Familial prostate cancer.