A marked reduction of Ang II-induced contraction in only 40-week SHR aortic rings with blocking of the AT2R-related signaling pathways (Figure 2) provided further information that reduced AT1R-contraction in aged SHR would result from any reduction of AT1R-related signaling cascade by hypertension regardless of enhanced AT1R expression with age. The gene discussed is AGTR1; the disease is Hypertension.