Furthermore, it has been shown that ΔNp63 is necessary to maintain the clonogenic and proliferative potential of the basal progenitor cells in stratified epithelial cells in vitro[37], [38], and inactivation of p63 results in increased expression of ink4a and Arf tumor suppressors and [39], thus linking p63 to the control mechanism of cellular senescence and apoptosis. This evidence concerns the gene CDKN2A and neoplasm.