Chronic Tempol administration has been shown to ameliorate oxidative stress and lower arterial pressure in various rat models of hypertension: spontaneously hypertensive rats (SHR) [12], Dahl salt-sensitive rats [13], mineralocorticoid-induced hypertension [14], lead-induced hypertension [15], and erythropoietin-induced hypertension in uremic rats [16]. This evidence concerns the gene EPO and hypertensive disorder.