One study of primary tumors in head and neck cancers using the markers CD44 and ALDH identified a subset of tumor cells that unique CSCs properties including self-renewal, capacity to form new tumors in mice and exhibited high metastatic potential (Prince et al 2007, Davis et al, 2010, Clay et al 2010) [16], [18], [19]. The gene discussed is LDHA; the disease is neoplasm.