RHOC and head and neck squamous cell carcinoma: Since the role of RhoC in STAT3 phosphorylation has not been established before, we analyzed the phosphorylation of STAT3ser727 and STAT3 tyr705 in the scrambled control and the RhoC knockdown cell lines and showed that there was a decrease in both p-STAT3ser727 (80–90%) and p-STAT3tyr705 (50–60%) in the RhoC knockdown HNSCC cell lines (Fig. 5A&B).