The loss of ITGB4 expression (Figure 3I) reduced the Shh-stimulated cellular invasion of SKOV3 cells by ∼60% compared with untreated or non-targeting (miR-control) miRNAi–transfected cells (Figure 3J), suggesting that ITGB4 is important for tumor cell invasion. This evidence concerns the gene ITGB4 and neoplasm.